Cells possess a variety of organelles such as a nucleus, mitochondria, ribosome, and others. We observed that TBC1D24 protein, encoded by the TBC1D24 gene, which is a JAG associated with epileptic encephalopathy, formed a novel "ring"-like macrostructures in cells (arrowheads in the picture). TBC1D24 protein is a GTPase and thus the macrostructure is considered to…
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JAGs and JALNCs
How are the juvenile properties established in juveniles? Children can grow, learn, adapt, mature, regenerate, and show resilience. Children and adults possess the same sets of genomes, but they are very different. One reason behind the difference is the usage of the genome. Children use a different set of genes for growth, maturation, and other…
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Cell competition and juvenility
Cell competition is the competitive relationship among cells. The loser cells of cell competition are eliminated from tissues thereby the tissue integrity is better maintained. The winner cells grow more. The phenomenon was originally found by Morata et. al with the "Minute" mutant of Drosophila (reference 1). We utilized neural progenitor cells that form neuroepithelium-like…
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