Bex1 is a juvenile IDP that mediates tubulin polymerization.
Bex1 mediates tubulin polymerization by providing reaction field that enriches GTP to optimize the polymerizing reaction.
We elucidated the new role of Bex1, a juvenile-expressed IDP (intrinsically disordered protein) for the generation of primary cilia. Bex1-KO mice present ciliopathy phenotypes that resemble a ciliopathy, Joubert syndrome.More info
Biology and Medicine